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GSH is also important in limiting and repairing the deleterious actions of NO, but unfortunately GSH levels can be depleted by extremely high concentrations of NO [23]

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Combined Skin-Lightening Agents Combined skin-lightening formulations started in the 1970s with the Kligman formula combining hydroquinone with tretinoin and corticosteroids used primarily to reduce hydroquinone-induced skin reactions [27, 94]