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Endogenous danger signals secreted from cells under pathological stimuli, including cell-free DNA, modulate intracellular proinflammatory signaling in an autocrine/paracrine manner through TLRs on the cell surface [15]

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Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-kappaB pathways in human lung epithelial cells

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Zheng X, Liu B, Liu X, Li P, Zhang P, Ye F, et al

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