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Effects of once-weekly subcutaneous retatrutide on weight and metabolic markers: A systematic review and meta-analysis of randomized controlled trials.

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Many studies have demonstrated the efficacy of lifestyle intervention [31, 38, 39] and some drugs approved for the treatment of T2D (metformin, thiazolidinediones, and acarbose) and obesity (orlistat) [32, 40] in preventing or delaying the progression of prediabetes to T2D, showing clearly how weight loss is the main mediator of this effect [38, 41]

[DOI] [PubMed] [Google Scholar] 74.Shintani T., Hirono C., Sugita M., Iwasa Y., Shiba Y
