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Dermatology and Therapy, 10 (6), 1345-1357

GLP-1 receptors exist in brain regions that regulate both appetite and the sleep-wake cycle, which may explain why sleep changes and appetite changes show up together

Final Takeaway Whether GLP-1 medication is used or not, long-term metabolic health depends on one foundation : A resilient microbiome healthy SCFAs stable GLP-1 lasting metabolic balance

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Lean patients should also be aware that semaglutide may cause unintended weight loss beyond therapeutic goals, nausea, and gastrointestinal side effects