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VF: Writing review & editing, Writing original draft, Validation, Funding acquisition

Buse, J.B

The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

Single-anastomosis gastric bypass and duodenal switch are associated with greater variability compared to RYGB and sleeve gastrectomy (SG)

Thyroid cancer did not increase

Tirzepatides additional GIP pathway may enhance insulin sensitivity and fat metabolism, though the exact mechanism is still being studied