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The FDA warning letter from February 20, 2026 cited misleading marketing language, not an unsafe product, but it is a documented compliance issue patients should factor into their decision

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The maintenance phase includes visits approximately every four months once stable

In addition, Ex-4 provides neuroprotection against ischemia-induced damage in the hippocampus by downregulating hypoxia-inducible factor-1 and modulating apoptosis through the increased B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X-protein (Bax) ratio, which is mediated by the GLP-1 receptor [48]

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This review aims to synthesize the available literature on the use of GLP-1 RAs in HS and psoriasis, evaluate their emerging clinical relevance, and identify areas where more research is needed