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Sweeney CT, Fant RV, Fagerstrom KO, McGovern JF, Henningfield JE

Buprenorphine is a partial opioid agonist, meaning it binds tightly to the brains mu-opioid receptors but produces a weaker, capped effect compared with full agonists like oxycodone or fentanyl

This reflects a tension in public health circles: given smoking is so addictive and damaging, is it acceptable or even ethical to reduce that harm by advocating products that are safer, but still not safe

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Cigarettes Marketed as Low-Odor or Odorless While no cigarette is completely odorless due to the combustion process, some products significantly reduce smell: 1

Phase two, the balance of the reengineered WisBar website, is targeted for launch in early 2012