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It is not clear whether sufficient amounts of pharmacologically active chemicals derived from these additives remain after pyrolysis

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Isomer ratios: Older synthetic production sometimes yielded small amounts of the less-active R isomer, but modern processes focus on pure S isomer, matching tobacco nicotine

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Drug services commissioning plans are engineering a shift towards recovery and re-integration for Class A drug users and upstream and therefore shorter interventions for younger substance users who are using cannabis, cocaine or legal highs

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