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NICE recommendations for GLP-1 therapy include: For type 2 diabetes (NICE NG28): GLP-1 therapy should only be continued if there is a beneficial metabolic response (HbA1c reduction of 11 mmol/mol [1.0%] and weight loss of 3% of initial body weight at 6 months)

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2 Materials and methods 2.1 General computational methods Protein Data Bank (PDB) coordinates of the GLP-1GLP-1R (5VAI) (Zhang et al., 2017), Semaglutide (7KI0), Taspoglutide (7KI1) (Zhang et al., 2021), and liraglutide (4APD) were retrieved from the RCSB PDB server (www.rcsb.org)

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