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Whats emerging here is a new paradigm where: neuronal energy metabolism becomes a therapeutic target

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The manifestations of mitochondrial dysfunction in AD mainly include increased oxidative stress and ROS production, 152,153 mitochondrial DNA damage, 154 mitochondrial respiratory injury, 155 and calcium abnormalities
23431, federalregister.gov, docket 2026-08552)

Metabolic effects beyond weight loss Both cagrilintide and retatrutide affect metabolic parameters far beyond the number on the scale
