tirzepatide semaglutide differences vs. Semaglutide: What You Should Know Comparative safety and side effects

Description

Lawsuits claim Ozempic, Wegovy, and other GLP-1 drugs cause serious side effects like gastroparesis

Five scientists won this years Breakthrough Prize in Life Sciences for their work on GLP-1 and the development of drugs for diabetes and obesity.

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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

Common AEs were nausea (23%), vomiting (6%), diarrhea (6%), constipation (10%), headache (6%), fatigue (8%), abdominal pain (2%), and abdominal bloating (2%)