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The public health burden of obesity has increased worldwide

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In addition to metabolic pathways, there was also significant enrichment in biological processes involving immune regulation, such as leukocyte migration, chemotaxis and myeloid leukocyte activation (Fig

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In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles