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Furthermore, increased levels of circulating free fatty acids, inflammatory cytokines (TNF-, IL-1, IL-6) and chemokines increase BBB permeability

Messier, S

The reasoning is that your GLP-1 receptor tolerance from semaglutide means the GLP-1 component of tirzepatide will not overwhelm your system, and the GIP component alone is unlikely to cause severe side effects at this dose

10.1001/jama.2017.14752 [DOI] [PMC free article] [PubMed] [Google Scholar] DeFronzo R
