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The choice of second-line agent depends on individual factors including cardiovascular disease, heart failure, chronic kidney disease, body weight, hypoglycaemia risk, and patient preference

For long-term success, they should be combined with: Nutrition counseling to support a sustainable dietary pattern Exercise and physical therapy to strengthen the back and core Behavioral coaching to build lasting habits Additionally, patients should avoid the temptation of using GLP-1 medications as a quick fix or without medical supervision

GLP-1 agonists can trigger or worsen acute pancreatitis

These findings might lay the foundation for the potential regenerative treatment of patients with chronic stroke

Pharmaceutical Manufacturer Initiatives Pharma companies (like Novo Nordisk, Lilly) also engage with ePA indirectly by providing patient support services

Data Availability The datasets generated during and or analyzed during the current study are available from the corresponding author upon reasonable request