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doi: 10.1016/j.yfrne.2007.10.005

Further supporting the role of Pax6 in regulating intestinal Gcg expression, adenoviral overexpression of Pax6 enhances Gcg promoter activity and Gcg expression in intestinal enteroendocrine cells such as the secretin tumor cell line-1 (STC-1) and cells derived from colonic tumors of transgenic mice expressing large T antigen under the control of the proglucagon promoter (GLUTag cells) [108]

But drug coverage alone isnt a weight loss benefit within a greater cardiometabolic health strategy

Overall, the favorable metabolic profile induced by GLP-1 RAs (weight loss and reduced caloric intake, improvement in glycemic compensation) allows one to hypothesize their potential effectiveness in the treatment of NAFLD, in addition to T2DM and obesity

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In review of GLP-1 receptor agonists surrounding the perioperative period, it was found that there is a variable association with GLP-1 RA use and the findings of RGC with most publications being limited to case reports, retrospective studies, and observational trials (Chang et al