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Moreover, GLP-1 triggers a change in conformation of its receptor, leading to the activation of a Gs protein and the production of secondary messengers

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Factors such as: Degree of insulin resistance Presence of other conditions (cardiovascular disease, fatty liver disease, sleep apnoea) Family history of diabetes or obesity Age and menopausal status Previous weight loss attempts and patterns of weight regain Safety considerations and tolerability play an important role

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