surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1
Description
Glucagon-like peptide-1 ( GLP-1 ): released later in a meal to regulate blood sugar and appetite
![surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1](https://www.healio.com/~/media/images/news/print/cardiology-today/2022/07_july/surmount1.jpg)
Despite likely being a similar tier as GLP-1 RAs and SGLT2is for many patient insurances, this elevated AWP is important to note for patients with co-insurances, deductibles, the Medicare coverage gap, patients without insurance, and for the total cost of healthcare
![surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1](https://heart.bmj.com/content/heartjnl/110/19/1165/F2.large.jpg)
Starting dose for Semaglutide: 0.25 mg weekly = 5 units (0.05 mL) on the insulin syringe provided
Figure 3 : Left (SURMOUNT I): weight reduction of 5%, 10%, 15%, 20%, and 25% or more at week 72 with tirzepatide 5mg, 10mg, and 15mg versus placebo
![surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1](https://pbs.twimg.com/media/HB2UAh7XgAA-x3t.jpg)
Movement matters too
![surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1](https://www.researchgate.net/publication/366107088/figure/fig1/AS:11431281455242588@1747976958963/SURMOUNT-1-study-design-This-is-a-phase-3-multicenter-randomized-placebo-controlled.png)
PlexusDx Compounded Tirzepatide Injection starts at $249/month with no insurance required
![surmount 1 tirzepatide In an earlier analysis of the SURMOUNT-1 trial, (a dual glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1] receptor agonist) was shown to provide substantial and sustained reductions in body weight SURMOUNT-1](https://ars.els-cdn.com/content/image/1-s2.0-S2667368126000045-ga1.jpg)