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Several GLP-1s are beneficial to heart health, but some patients report a slightly elevated heart rate while on them

On the other hand, it was demonstrated that chronic stress in laboratory animals can shift the microbial diversity in the gastrointestinal tract [102, 103]

Current evidence suggests a risk-stratified approach, with most patients able to continue therapy with appropriate precautions, while some higher-risk individuals may benefit from temporary medication adjustments

Considering route of administration, the market is divided into parenteral and oral

Thus, to effectively treat MASH, a drug must address three key conditions: fat accumulation, inflammation, and fibrosis

Full safety data from all seven TRIUMPH trials will provide a more complete picture as results are published throughout 2026