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[DOI] [PMC free article] [PubMed] [Google Scholar] Pratley R., Nauck M., Barnett A., Feinglos M., Ovalle F., Harman-Boehm I., et al
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96 The study of cholecystectomy in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has highlighted the importance of bile acid signaling pathways, including FXR and TGR5, in the maintenance of metabolic and biliary health

Curcumin , some preclinical evidence suggests curcumin may upregulate GLP-1 secretion, though human data is limited

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Both receptors exist in brain regions that regulate appetite, and their combined activation produces stronger appetite suppression than targeting either receptor alone
