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Data Sharing Statement: See Supplement 2

THE FUTURE AND THE OTHER PEPTIDES, HORMONES AND COMPOUNDS THAT CONTROL METABOLISM Focus on GLP-1s role in prevention, reversal, and control of obesity overshadows the complex physiology of metabolizing food and regulating caloric intake

2 , 3 , 4 , 5 , 6 The results of the SURPASS-2 study showed that individuals who had established T2DM and were treated with tirzepatide at doses ranging from 5 to 15 mg for a duration of 40 weeks experienced a reduction in HbA1c levels ranging from 2.09% to 2.46%