injection site burning semaglutide Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports - JDDonline Why Semaglutide Injections Burn: Relief

10.3389/fendo.2020.00267 Front Endocrinol

We recommend using a 3ml or 5ml syringe with a needle gauge of 21g or similar for drawing and transferring the diluent

Common gastrointestinal side effects include: Nausea often the most prevalent side effect, typically diminishing over time Vomiting and diarrhoea usually mild to moderate in severity Abdominal pain and decreased appetite Constipation and dyspepsia (indigestion) These effects are generally most pronounced when starting treatment or increasing the dose, and often improve as treatment continues

Different pharmacies use different concentrations, different vial sizes, and sometimes different additives

**Heart rate (unique to retatrutide):** Glucagon activation causes a modest 5-10 bpm increase in resting heart rate

Even if you were comfortable on semaglutide, your body needs time to recognize the new GIP signal