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These observations point to a cross-talk between circulating GLP-1 and the brain, but the relative importance of peripheral versus central GLP-1 for the control of glucose homeostasis is not known

doi: 10.3390/ijms23179583 [DOI] [PMC free article] [PubMed] [Google Scholar] 108

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And the before and after semaglutide article provides real-world context for the range of outcomes people experience

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Common side effects associated with GLP-1 receptor agonists include nausea, decreased appetite, and gastrointestinal discomfort, particularly during early dose titration