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GIPs action is mediated via the GIP receptor (GIPR), a G protein-coupled receptor

Individuals with type 2 diabetes have higher rates of osteoarthritis, and obesity itself is a major risk factor for joint disease

In SELECT, a trial of more than 17,000 people on semaglutide, serious adverse events were actually lower than on placebo, about 33 percent versus 36 percent (Lincoff et al., 2023)

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Published research has further examined Retatrutide in models relating to insulin sensitivity, lipid metabolism, cardiovascular markers, and hepatic fat reduction pathways

We uncover topics around weight loss, side effects of different GLP-1 RAs, and concerns about drug access and supply, with a mainly neutral-to-positive view of GLP-1 RAs, highlighting the role of an AI-enabled pipeline to help monitor for emerging side effects, uncover public sentiment, and guide future directions for research and public health efforts