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& McClendon, C

BioXconomy recently reported on a landmark study that showed GLP-1s cut mortality and hospitalization rates from heart failure by 40%, potentially independent of their weight loss effects

A review of 39 human and animal studies on the topic, however, reached a concerning conclusion that GLP-1 agonists reduce fetal survival, weight, growth, and skeletal ossification and can induce major congenital anomalies (152)

Its a small trial with only 1-year follow up and lacking hard endpoints such as hospitalization or cardiovascular deaths, but the results for symptomatic relief and gain in physical activity are certainly very encouraging

For example, in a study conducted by Nathanson et al

Oct 2024: A multi-society guidance (ASA, AGA, ASMBS, SAGES, etc.) concluded most patients can continue GLP-1s before elective surgery/endoscopy, with risk-stratified adjustments like liquid diet day prior, point-of-care gastric ultrasound, or brief hold for high-risk situations like active GI symptoms or rapid dose escalation