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In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)

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[DOI] [PubMed] [Google Scholar] 44.Beak S.A., Small C.J., Ilovaiskaia I., Hurley J.D., Ghatei M.A., Bloom S.R., Smith D.M

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Also, anti-proliferative effects on smooth muscle cells and anti-inflammatory effects on macrophages may contribute to the protection against the development and progression of atherosclerosis [8-10]

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Hence, the risk of cholelithiasis should be considered and addressed in patients treated with GLP-1RAs [11]

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In this regard, GLP-1RAs can provide the protection against VSMC senescence via increasing the nuclear factor erythroid 2-related factor 2 (Nrf2) activity [122]

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