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Research has suggested GLP-1s may reduce the risk of heart attack and stroke in people with diabetes or obesity

Dietary modifications form the cornerstone of management: Reduce sulfur-rich foods : Temporarily limit consumption of red meat, eggs, dairy products, cruciferous vegetables, garlic, onions, and protein supplements Avoid trigger foods : Identify and minimise foods that personally exacerbate symptoms, such as processed foods, carbonated beverages, and artificial sweeteners Increase fibre gradually : A balanced fibre intake supports healthy gut motility, but introduce it slowly to avoid worsening bloating Stay well-hydrated : Adequate water intake (approximately 68 glasses daily) supports digestion and helps prevent constipation Eating habits and lifestyle adjustments can significantly impact symptom severity: Eat smaller, more frequent meals rather than large portions Chew food thoroughly and eat slowly to reduce air swallowing Avoid lying down immediately after eating

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This effect is more clear in animal studies, where weight-matched controls are easy to achieve by restricting access to food and any changes in diet are controlled for

But in most cases, weve seen that patients exclusively seeking weight loss usually need higher doses of the same drug

Animal studies have demonstrated Berberines anti-obesity mechanisms, including the inhibition of adipocyte differentiation through downregulation of adipogenic genes such as Liver X Receptors (LXRs), Peroxisome Proliferator-Activated Receptors (PPARs), and Sterol Regulatory Element-Binding Proteins (SREBPs)