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Comparing the results from the various trials [33,38,42,43,44,47,48], the average weight loss is about 3.46.1% of the total body weight

Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)

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GLP-1 agonists trigger the pancreas to release insulin, lowering the amount of glucose (sugar) in the blood

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Since then, Wegovy has gained additional approvals for use in pediatric patients aged 12 and older with obesity and to reduce the risk of MACE in adults with established cardiovascular disease who are overweight or obese