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Description
-Cell GLP-1 in normal glucose regulation The accepted dogma of GLP-1 secreted from the intestine and acting on the pancreas in an endocrine manner is difficult to reconcile given the observations that GLP-1 is rapidly degraded by dipeptidylpeptidase 4 (DPP4) and very little, in fact, only approximately 10% of intestinally secreted GLP-1 reaches the circulation (39, 82, 93)
In a randomized clinical trial , adults with obesity or overweight (but without diabetes) who took Saxenda experienced an average weight loss of 6.4% in 68 weeks (about a year and a half)
Apovian said many of her patients have obesity and diabetes

more patients coming to them which were never their clientele earlier and getting treated better than any other medication - word of mouth Orals are also being launched I think it was over estimated for the short term and now being underestimated for the long term Mounjaro has become 0.8-0.9 % of the indian market no other drug is even half of it and that it in about 18 months

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CrossRef SGLT2 Inhibitors and Diabetes: Where Does It Come from and Where Does It Go