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Gradual titration from the lowest dose is always the safest approach when introducing a new compound with a different mechanism of action

They are hormone-like drugs that help your own pancreas release insulin in a more natural, glucose-dependent way and also reduce excess sugar from the liver and help you feel full sooner

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Prokinetic agents like metoclopramide present a theoretical option but should be used cautiously given potential adverse effects (including tardive dyskinesia with use beyond 12 weeks) and the counterintuitive nature of accelerating gastric emptying while using a medication that intentionally slows it

L., & Habener, J