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Description
[7-9] For sitagliptin, no differences in cardiac events were observed compared with placebo in an analysis of 5,429 patients, [7] and similar results were found for vildagliptin against all comparators in data from 7,509 patients

Mol Metab 64:101550

What Makes New GLP-1RAs Different
The Trump administration announced initiatives in November 2025 to expand GLP-1 access for Medicare beneficiaries with obesity plus significant comorbidities, with implementation expected around mid-2026

26% with placebo, Tables 2 and 3)

113 This could be the paradigm in which GLP-1RAs are indicated for MASLD with complications
