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This publication has not received compensated product samples for testing, has not interviewed Shed personnel, has not been granted access to internal product specifications beyond what is publicly published, and has not conducted laboratory or field performance testing

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While most GI side effects (nausea, diarrhea, constipation) are shared between both medication classes, some patients find tirzepatides side effects more intense or persistent than they can manage, even after giving the body time to adjust and trying different doses

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Wild-type (WT) mice on a C57BL/6J background mice were also purchased from the Jackson Laboratory (stock# 000664)

Patients with a history of pancreatitis (inflammation of the pancreas) or those who have had thyroid cancer or a family history of medullary thyroid cancer should avoid semaglutide due to potential risks