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The integration of gustatory sensory signals occurs primarily in the orbitofrontal, prefrontal, and insular cortex (110)
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The two brands differ in FDA-approved indication only: Zepbound is approved for chronic weight management and sleep apnea in obesity, while Mounjaro is approved for type 2 diabetes
Meanwhile, this article focuses on evaluating the evidence of the current effects of GLP-1RAs on patients body composition, muscle mass and function in clinical trials, deeply explores the dual effects and heterogeneity of its efficacy, and analyzes the translational dilemma existing between preclinical positive discoveries and clinical outcomes.Furthermore, for the elderly population, this article further discusses the tolerance and nutritional risks faced during the treatment of GLP-1RAs
