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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Buhl T, Thim L, Kofod H, Orskov C, Harling H, Holst JJ

Discovery of the once-weekly GLP-1 analogue semaglutide

Still, like other alternative sweeteners, allulose may cause adverse effects in certain people

This may be partly mediated by improvements in weight loss and glucose control

Adverse event reports submitted to the FDA have highlighted severe gastrointestinal issues, such as gastroparesis and bowel obstruction, associated with Ozempic and similar drugs

4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation