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Any injection site reaction that persists beyond one week or progressively worsens should also prompt clinical evaluation to ensure appropriate management and rule out alternative diagnoses

With retatrutide and other multi-agonists on the horizon, we may soon see drugs that approach the effectiveness of bariatric surgery without the invasiveness

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GLP-1 receptors in the gastrointestinal tract are present at higher density than hypothalamic satiety receptors, meaning gut-related nausea appears at lower doses than appetite suppression