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Abstract Obesity is a chronic, relapsing disease associated with multiple complications and a substantial morbidity, mortality and health care burden

13,140 Animal studies have shown that neutral antagonists appear to decrease food consumption and weight gain similar to Rimonabant, but unlike this drug they do not inhibit activity in areas of emotion regulation, such as the ventral tegmental area and the basolateral amygdala

GLP-1 medications tend to produce relatively rapid fat loss, which increases the likelihood of excess skin compared to gradual weight loss through diet and exercise alone

What was particularly striking in our data was just how fast it was regained, he said

Early experience with customized, meal-triggered gastric electrical stimulation in obese patients