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UK SmPCs advise caution in patients with personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2

The NHS and NICE Clinical Knowledge Summary (CKS) for Insomnia recommend cognitive behavioural therapy for insomnia (CBT-I) as the first-line treatment for persistent sleep problems

Key questions to discuss include the expected benefits and risks specific to your situation, alternative weight management strategies, and realistic expectations for weight loss outcomes

In one example, a Facebook page called Emma Davis, which claimed to be a team of specialist in diabetes care and weight management based in New South Wales, ran advertising for a product it claimed was a GLP-1 plant based oral solution

The outcomes from secondary endpoints showed that 0.9% versus 1.9% of patients died from CV causes (HR 0.49, 95% CI 0.270.92)

What makes them safe in practice is the monitoring regular lab work, body composition tracking, and provider check-ins ensure we catch anything worth adjusting before it becomes a problem