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The 0.5-milligram starting dose is designed to minimize side effects
Widely used for type 2 diabetes mellitus and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) may increase risk for injection-site reactions, especially exenatide and dulaglutide (Trulicity, Eli Lilly)

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Retatrutide showed superior reductions in albuminuria, glomerular hypertrophy, and renal fibrosis markers

However, when combined with a sulfonylurea (which forces insulin out regardless of glucose), the combo can cause lows
