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Patients with established cardiovascular disease (heart attack, stroke history) who benefit from semaglutides proven MACE reduction (SELECT trial) Adolescents aged 1217 with obesity Wegovy is the only approved GLP-1 option in this age group Patients who prefer or need an oral medication option (Rybelsus tablets for type 2 diabetes) Those for whom semaglutide is more affordable or better covered by insurance Patients with metabolic dysfunction-associated steatohepatitis (MASH) Wegovy HD received approval for this indication in 2025 First-time GLP-1 users who want to start with the medication with the longest real-world safety track record Frequently Asked Questions Is tirzepatide stronger than semaglutide

Retrieved August 9, 2022, from Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, Rodrguez

GLP-1 makes people feel full, which helps them eat less

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This mechanism has implications for the estimated 100 million Americans with fatty liver disease, many of whom have no effective pharmacological treatment options