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Abstract The aim of this narrative review is to critically assess the renoprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in managing albuminuria among patients with type 2 diabetes mellitus within the framework of personalized medicine

1 In one placebo-controlled trial with semaglutide (Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes [SUSTAIN 6]), 10 there was a significant early increase in diabetic retinopathy in patients allocated active therapy, which has been attributed to the rapidity and magnitude of improved glycaemic control (as has been observed in previous studies involving intensive insulin treatment) rather than being a direct adverse drug effect

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