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Stimulation with GLP-1 RAs resulted in a modest increase in calcitonin release and expression in primary rat thyroid cultures

If a consumer can buy Wegovy or Zepbound for $350 directly from the manufacturer, employers are right to ask: Why should our health plan pay more than an individual paying cash? This transparency sets the stage for employers to push for: Mid-cycle GLP-1 repricing or rebate true-ups Most-favored-net clauses guaranteeing parity with manufacturer DTC pricing Dose-specific caps to prevent runaway spend as members titrate upward Even without an immediate financial impact, this public price signal changes the tone of employer-PBM negotiations heading into 2026

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Can I stop taking GLP-1 medications once I reach my goal

For primary tissue, all three deconvolution methods reflected lower Myeloid Dendritic Cell enrichment in GLP-1R-high patients compared to GLP-1R-low ( Figures 4ac )