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10.1093/molehr/gar037 21 CapraE.TurriF.LazzariB.CremonesiP.GliozziT

352,435,485 Metabolic disease also reduces sex hormone-binding globulin (SHBG) production due to liver dysfunction and increased inflammatory cytokines

Critically, sophisticated EEG analysis confirmed no sedation in the classical pharmacological sense establishing that DSIP sustains natural sleep functions rather than inducing pharmacological sedation