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Molecular studies utilizing siRNA directed against TGH-2 in 3T3-L1 adipocytes demonstrated a 10% decrease in isoproterenol-stimulated glycerol release, while TGH-2 overexpression was found to increase glycerol release by 20%

Approximately one year later, he experienced a severe worsening of his previously very mild neuropathy, and lab evaluation yielded a serum B12 of 220 pmol/l (which is normal, remember!?), but an elevated serum MMA of 1300 nmol/l, supporting the existence of true B12 deficiency