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Like other miRNAs, miR34c can inhibit the transcription or initiate the degradation of target gene mRNAs by binding to the 3UTR (89)

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NF - B inhibition prevents CS-induced upregulation of MuRF1 and CS-induced reduction in the diameter and degradation of the MyHC -related C2 myotubes [2], suggesting that inflammation is responsible for CS-induced proteasomal degradation in skeletal muscle

Mihara, M