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Reduction in facial hyperpigmentation after moisturizers with niacinamide

Jixian Zhai, Sylvain Bischof, Haifeng Wang, Suhua Feng, Tzuu-fen Lee, Chong Teng, Xinyuan Chen, Soo Young Park, Linshan Liu, Javier Gallego-Bartolome, Wanlu Liu, Ian R
Alan Gaby MD (Alternative Medicine Review, 2002, PMID 12410623), the standardised protocol is best individualised based on the patients blood work and clinical presentation

10.1038/s41598-024-54971-4 3

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Why Dosing Adjustment Is Not Optional Women typically require lower doses than men because estrogen enhances GH receptor sensitivity
