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Description
This first wave of GLP-1s were commercially successful (Victoza saw peak sales of ~$3.8B in 2018), but results were modest relative to todays market

However, stricter FDA rules are now in effect, banning certain compounded GLP-1s and making it more difficult for many Americans to secure the drugs, especially if using it for weight loss reasons

and (iv) patients not treated with either GLP-1RA or SGLT2-I
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Why am I not losing weight on Topamax

GLP-1s slow down stomach emptying and could encourage stomach paralysis in people at risk

Figure 12: Photograph Professor Vincent Marks (1930-2023), credit: Seaton)