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Extensions of the external validation for checking learned model interpretability and generalizability

A 2015 review by Verdin (Gladstone Institutes / UCSF), published in Science , established that cellular NAD+ concentrations change during aging and that modulation of NAD+ usage or production can prolong both healthspan and lifespan
Nevertheless, mild BSO-stress did not affect concentrations of glutathione in mitochondria, even though glutathione was reduced in most other cell compartments in roots and leaves (Zechmann et al., 2006)

Additionally, this strategy facilitates multiplex gene editing and significantly reduces the risk of CRISPR off-target effects due to the transient activity characteristic of RNP delivery (206)
