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In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect

The medication is dosed by frequency (once weekly), not by body weight or sex

This cycling approach, sometimes called calorie cycling, optimizes both fat loss and muscle preservation across the week

J Mol Neurosci

In one major trial, participants lost up to 21.4% of their body weight over 72 weeks

Your physician may use DEXA scans or bioelectrical impedance analysis, which we complement with functional measurements