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Weight loss occurred primarily through reduced caloric intake facilitated by the medication's appetite-suppressing effects

Participants were randomized to receive either 6, 12, or 36 milligrams of orforglipron or a placebo pill

6 According to this new framework, people with a BMI of 25 or higher would be classified as having obesity if they also: Have a waist-to-height ratio of 0.5 or greater Have been diagnosed with medical, functional, or psychological issues related to excess body fat, such as elevated blood glucose, chronic low-grade inflammation, poor sleep, or binge eating

For many Americans today, food is abundant and cheap

Low-fat cottage cheese topped with diced peaches (fresh or packed in water)

doi: 10.1016/j.neuron.2020.03.009