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The knowledge of addiction often starts with a question like, what is the most addictive drug? The answer to such a question is not simple, as certain factors influence addiction, such as the rate of dependency, its effect on brain activity, and difficulty in quitting it

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this helps explain the counter-intuitive reduced risk of Alzheimers in smokers, despite their increased risk of cardiovascular disease, which is strongly correlated with Alzheimers incidence

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