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When researchers tested pure GLP-1 receptor agonists, including semaglutide , liraglutide, and exenatide, none of them increased the beating rate of isolated heart tissue

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demonstrated that irisin serum levels in PWS patients were similar to those of controls (95), however, both pediatric and adult PWS subjects with del15q had lower irisin levels compared to controls, whereas no difference was observed between PWS subjects with mUPD and healthy controls

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